Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
American brands such as Chipotle, Texas Instruments and General Dynamics are on the list for the first time.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
You'd love to know the balance of forces that shape and move your ponytail, right? That's why Joseph Keller, Raymond Goldstein, Patrick Warren and Robin Ball received this igNOMINIOUS prize!
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Before becoming Germany's top trading partner, China was Germany's largest trading market in Asia. Germany has been China's top trading partner in the European Union for the last 2 years.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
"I'm not really worried about it, honestly," Bryant said. "My shooting will be better."
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The demagogue’s campaign leads naturally to despotism — the tyranny of the majority that is a mask on the tyranny of one.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The first is the establishment of the Aero Engine Corp. of China (AECC) last year, which consolidates Chinese aero-engine know-how and capabilities, indicating that the indigenous development of aircraft engines is now a strategic priority for China. This focus is even more striking when one realizes that China now has access to rhenium, a rare metal that helps create strong superalloys necessary for the manufacture of high-pressure jet engine turbine blades. Since the 2010 discovery in the Shaanxi province of reserves, which account for 7% of the world’s total, considerable effort has been made to exploit and process this metal. Moreover, a major technological milestone was recently achieved that opens the door for mass production of single-crystal turbine blades, a key component of modern jet engines. It is thus no surprise that one of the cornerstones of the newly established joint Sino-Russian widebody aircraft program is the development of a dedicated, state-of-the-art engine.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
In P2P lending, borrowers are matched with investors, who are encouraged to put their money into the loans due to higher returns than they could get at state banks.
Armistice Day became an official U.S. holiday in 1938, and remained so until 1954, when it was renamed Veterans Day in the aftermath of both World War Two and the Korean War. It is separate from Memorial Day, which is observed on the last Monday in May and honors servicemen and women killed in war.
"The articles were submitted with reviewer suggestions, which had real researcher names but fabricated email addresses," Peter Butler, editorial director for cell biology and biochemistry at Springer Nature, told Shanghai-based news website The Paper.
Influenza neuraminidase: A druggable target for natural products
Brazil lost that 1950 final, 2-1, to Uruguay, a historic humiliation that still stings Brazilian fans today. Belmonte, 85, hopes he'll get to see his country regain its honor. "I hope Brazil will be able to win this time," he said. "This is our revenge. I want to go see our revenge."
Dachis says: Kraft took a stance in support of genetically engineered foods midway through the year and the decision turned their brand into an overall loser for 2012.
In 2012, Google introduced Google Glass, a computer you can wear on your face. Someone wearing the glasses can be walking down the street or doing any everyday task while simultaneously seeing an overlay of calendar appointments, messages, and subway alerts. They can make video calls and even upload live videos to the Internet while on the move, without ever needing to use their hands. Google Glass might be cool, it might be new, it might be revolutionary, but it's definitely not the first pair of wearable computer glasses.
Still, the optimistic view is that several roadblocks to recovery -- an over-indebted consumer, a moribund housing market and shellshocked banks -- are no longer holding back hiring. Barring an unforeseen shock to the economy, this could mean 2013 will be another year of slow but steady growth.[qh]
Doing more to unleash the potential of domestic demand
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
May your New Year be filled with special moment, warmth, peace and happiness, the joy of covered ones near, and wishing you all the joys of Christmas and a year of happiness.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
A New Year greeting to cheer you from your daughters.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Wages will finally accelerate after years of stagnation
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Trailing behind "Game of Thrones" on the most downloaded list are "Breaking Bad" and "The Walking Dead." Here is the list of 2013's most-downloaded TV shows (single episode) according to data collected by TorrentFreak and BitTorrent trackers:
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Please accept my sincere wishes for the New Year. I hope you will continue to enjoy good health.
Type D personalities usually have a low self-esteem and a great fear of disapproval and this is the primary reason that prevents them from opening up to others.
Comedy Series: “Veep” (HBO)
n. 慈善，慈善机关(团体), 仁慈，宽厚
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Another love ballad for Bond, but if Nancy Sinatra's song from You Only Live Twice was playing at your orthodontist's office, it would be the sexiest orthodontist's office in town. There's a mysterious quality to the string section, and a playfulness to the declining notes. They combine to make something rather magical. From here on out all of the Bond songs on this list are bona fide classics.
These artificial ears will be a huge benefit to those who suffer injuries or who have microtia, a condition that keeps the ears from ever developing.
To put this all in a bit more perspective, the current World Cup is averaging more goals than any of the top leagues around the world averaged in 2013/14. TheNetherlands' Eredivisie was the highest scoring of the top European leagues at 3.20 and the Bundesliga was just a shade behind at 3.16. No other top European league averaged more than 2.80 last season. In theAmericas, Major League Soccer is the current pace setter at 2.89 goals per game.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Google's UK results are split into trending searches and most searched.
For Maddie Ziegler, from Pennsylvania, life couldn't be more different.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
“The Diary of a Teenage Girl” (Marielle Heller)
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Mr. Wang, the WeChat user in Beijing, said he was an avid QQ user 11 years ago but stopped using the instant messaging service because 'it didn't look very professional.' But after downloading WeChat on his smartphone he found 'most of my colleagues and friends are on it, and everyone communicates through voicemails now.'
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
It is believed that the rise of South Korea's pop music industry is behind the boom, and many patients visit clinics with photos of celebrities, asking surgeons to emulate nose angle or eyes.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
A moment of panic followed, before the teenager decided to take matters into his own hands and find a way out.
Included will be messages about smoking causing cancer and women who give the charmer a run for his money as 'little twists' have been added to make the story suitable for the modern reader.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Market watchers were forced to digest the reality of negative 2.9% GDP for the first quarter of the year. All of a sudden, everyone’s forecasts seemed too rosy—or at least too smooth—compared to the lumpy reality. This led to a raft of second-guessing on the timing of the Fed’s eventual exit from its bond-buying stimulus program. We went from confidence to WTF? in a space of a few weeks, with all the asset class rotations and market corrections that come along with a fresh bout of uncertainty.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
The line of prescriptive frames and sunglasses, named “DVF | Made for Glass,” costs upwards of $1,600. Google has already partnered with Luxottica, the eyewear conglomerate behind Ray-Ban and several high-fashion eyewear offerings such as Prada. It also hired fashion executive Ivy Ross, most recently the chief marketing officer of Art.com, to lead its Glass team.
In this case, the Lakers got a reasonable return for their top trade piece, prepared to give their young players like D'Angelo Russell and Brandon Ingram greater responsibilities down the stretch, and hunkered down for a tank that just might land UCLA star Lonzo Ball.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
格温妮丝·帕特罗（Gwyneth Paltrow）曾出演《莎翁情史》（Shakespeare in Love）获最佳女主角奖，并成为好莱坞明星。为了避免在发表获奖感言时出现混乱，她却把小金人藏了起来，因为“这东西吓坏我了”。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
"Hiring a veteran can be one of the best decisions any of us can make, and Wal-Mart is proud that we have hired more than 26,000 since we announced our Welcome Home Commitment on Memorial Day," Simon told Fortune. "Veterans have a strong record of performance under pressure and passion for service, which makes our pledge to hire, learn from, and support them easy."
Supply-side structural reform: Cutting overcapacity, destocking, deleveraging, reducing costs and identifying growth areas
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
“Nick is an exceptional product thinker,” Adam Cahan, Yahoo’s senior vice-president of mobile and emerging products, said. “He does represent a generational shift in the kinds of things he is thinking about and what it means to be truly mobile. That generation is not just mobile-first, they are mobile only. That’s a different point of view.”
全球新职介绍公司Challenger Gray & Christmas 的执行总裁John Challenger 说：“经济不景气之后，总会有个就业复苏期，但是我们的确对2010年的就业率不抱多少乐观态度。”
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
The other issue with tanking is Philly, Phoenix, and Brooklyn are all bad teams. It's going to be hard to outflank those outfits.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
华尔街、大街上和华盛顿的每一个人都在不断地忘记市场周期的基本原理。请记住：《笑傲股市》(How to Make Money in Stocks)作者、《投资者商务日报》(Investors Business Daily)的比尔?奥尼尔(Bill O'Neill)说，市场的上行周期平均为3.75年，下行周期平均为九个月。
It's the summer of 1983, and precocious 17-year-old Elio Perlman is spending the days with his family at their 17th-century villa in Lombardy, Italy. He soon meets Oliver, a handsome doctoral student who's working as an intern for Elio's father. Amid the sun-drenched splendor of their surroundings, Elio and Oliver discover the heady beauty of awakening desire over the course of a summer that will alter their lives forever.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Author Anthony Horowitz has revealed the new book Trigger Mortis has been amended for modern readers and contains anti-smoking messages and for the first time an ‘outspoken’ gay friend.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Fantastic Beasts and Where to Find Them will be released worldwide on November 18, 2016.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
同时，美国Rapper歌手Eminem被证明是“复出王”，摘得最佳Hip Hop歌手奖。”The Lose Yourself ”的创作者与Hip Hop的新面孔相互竞争，包括Drake, Future, Kendrick Lamar and Post Malone。
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
门萨智商测试的参试者必须是超过十岁半的儿童，测试包括两部分独立的行业标准评估。一部分主要测试语言推理能力;而另一部分包含表格和图形，测试视觉和空间逻辑能力。而来自坦姆赛德的妮诗在第一部分卡特尔III B测试中得到了最高的162分，在第二部分的文化能力量表(Culture Fare Scale)中得到了142分，该测试结果使她名列英国智商最高的前1%人群，而门萨测试成绩前2%的参试者都可以成为门萨会员。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
adj. 故意的，有意的；打算中的 n. 已订婚者 v.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
A Beautiful China where the sky is blue, the land is green, and the water runs clear
If the timing of your job search allows, Foss recommends beefing up your LinkedIn profile gradually (and thus inconspicuously). Or better yet, work on it when you're not job searching。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Yao has been at the center of a hostile takeover battle for China's largest real estate developer China Vanke Co Ltd (000002.SZ).
10. The 2012 Ig Nobel Prize in Medicine
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The standout is "Him," a tear-jerker about queer love and cultural intolerance that, in its understated way, is an LGBTQ civil rights anthem.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
When it’s time to buy a new car, you have 36 brands to choose from. Each automotive brand has something to offer, but not every brand is right for every buyer. Some brands excel at making performance cars, others focus on making family-friendly crossovers or specialize in luxury cars.
Anti-HIV drug repurposing against SARS-CoV-2
GAINS AND LOSSES IN A CHANGING WORLD
The worries stretched from the global, such as Russian attempts to influence the US presidential election in 2016, to the local — concerns about users’ mental health and the drain on productivity as they drown in notifications and news feed posts.
Length-scale dependence of protein hydration-shell density
One of the things that makes Guardians such a great superhero franchise is its sense of humor—which is full of self-deprecation and sarcasm. It's not like you're going to watch this movie and laugh your way through it, but you'll at least have some moments of "ha ha, Groot," and "lolololol Chris Pratt."
这类开发项目之一，是邓波区(Dumbo)的沃特街(Water Street)60号，一个包含290个单元的出租楼盘，带有24小时门房服务和一个可坐拥曼哈顿景观的屋顶平台。房屋租赁将于下个月开始，两居室的每月房租起价达到了令人瞠目结舌的6018美元（约合人民币3.7万元）。“人们想要体验住在共管公寓的生活，即使他们是租房而不是买房。”花旗居屋负责新开发项目的董事总经理乔迪·安·斯塔斯(Jodi Ann Stasse)说。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Release date: Spring 2015
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The proportion of enrolled female students has increased steadily since the ranking began six years ago to 42 per cent among the most recent cohorts. This is low compared with the 48 per cent of female students on masters in management courses but compares favourably with the 35 per cent in MBA programmes.
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She is now so successful that her mother has hired a security team who monitor the star 24/7.